Carbohydrate microarrays have been used in glycomics research to examine the interactions of carbohydrates with other molecules. The chip-based format of microarrays offers important advantages over common screening techniques, such as enzyme-linked immunosorbent assays (ELISAs), because several thousand binding events can be screened on a single glass slide & only minuscule amounts of analyte and ligand are required. Assay miniaturization is particularly suitable for glycomics, because access to pure oligosaccharides is the limiting factor. The first carbohydrate microarrays relied on isolated saccharides that were non-covalently attached to membranes. Current screening efforts rely on carbohydrate arrays in which chemically or enzymatically synthesized & isolated oligosaccharides with a linker on the reducing terminus are covalently attached to glass slides. Standard DNA printing and scanning equipment is used to produce & analyse the carbohydrate microarrays Carbohydrate microarrays can be used to address the interactions of sugars with other types of molecules, as well as entire cells. Carbohydrate-RNA interactions were screened by incubating labelled RNA with aminoglycoside microarrrays. Mechanisms responsible for antibiotic resistance were studied using these arrays together with resistance-causing enzymes.
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Molecular Depot LLC specialize in the development of research tools and biochemicals. Our products include specialty bacterial culture media, antibodies & antigens, enzymes & proteins, chemical compou
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Qiagen, Inc. provides sample & assay technologies to academic research markets, pharmaceutical & biotechnology companies, and molecular diagnostics laboratories. We offer products for genomic DNA prep
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Molecular Biology Insights offers primer analysis software for designing and analyzing sequencing & PCR primers, synthetic genes & various kinds of probes including siRNA & molecular beacons. Our olig
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Dharmacon, Inc. develops and delivers technology for RNA oligonucleotide synthesis. We offer RNAi-related products for investigating the mechanisms of siRNA (small interfering RNA) induced gene knockd
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Integrated DNA Technologies specializes in the areas of gene silencing based on RNAi, ddRNAi and antisense technologies, transcription profiling, DNA sequencing and SNP detection, microarray analysis
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Tribiosys, Inc. designs & develops solutions for analyzing and managing R&D data & processes for pharmaceutical, biotech & medical-device companies. Our services include scientific computing, laborato
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MWG Biotech, Inc. offers unmodified custom oligos, high-quality custom oligos in tube format, real-time PCR probes, modified custom oligos and high throughput oligos. We also offer single-read sequenc
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Sussex Research Laboratories Inc is a private company. We design & manufacture advanced glycosylation products & synthesis solutions for biopharmaceutical, diagnostic and research applications. Our pr
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