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Specific phenotypic tests, such as body weight measurements, intraperitoneal injections, blood collection & urine testing can be performed subject to approval by the Animal Ethics and Experimentation Committee. The facility can also provide clinical chemistry analysis, flow cytometry and microarray analysis of tissues or sorted cells. Expert advice on developing or evaluating the results of specialized phenotyping tests is available through the network. Standard Phenotyping Services are, blood collection by retro-orbital bleed, tail vein, saphenous vein, jugular catheter and vena cava (attermination), blood samples are used for monitoring fasting & fed glucose levels in diabetic rats (T2DN,Zucker), isolation of either plasma or serum from blood for measurement of clinical chemistries or drug levels, ?24-hour urine collection for measurement of biomarkers for renal damage due to disease (nephropathy,ESRD) or drug toxicity, biomarkers include, but not limited to proteinuria & glucosuria, clinical chemistry analysis for measurement of biomarkers for kidney (BUN,creatinine), liver (ALT, AST, SDH) & heart (CK) damage, histopathology that includes organ preservation, generation of tissue slices, staining and scoring by certified pathologists. EUMORPHIA is an integrated research programme involving development of new approaches in phenotyping, mutagenesis & informatics leading to improved characterisation of mouse models for the understanding of human physiology and disease.
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The use of pheromones to achieve biological pest management is an ingenious alternative to using harsh chemicals and a great way to reduce pesticides. Insects of the same species can communicate with one another by releasing small quantities of chemical substances from their bodies into the air. These distinct 'scents', which are called pheromones, will attract others to the source of that attraction. The action of the pesticides, which contain a mixture of insect pheromones, is vastly different from that of previous-generation pesticides such as malathion and other organophosphates, which indiscriminately wipe out any bug in their path. In this case, the pheromones are normally produced by female moths. An artificially applied source of the pheromones diverts the attention of the males, resulting in less mating and smaller moth populations. It is now possible to communicate with certain insects by using these synthesized pheromones, enabling us to attract them, or disrupt them from their normal behaviour .
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