Profile: Stemgent, Inc. develops small molecules for stem cell research. These molecules offer many advantages such as easy cell penetration, low antigenicity, versatility to work across multiple cell signaling pathways, and to effect epigenetic modifications as well. Our Stemolecule™ SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells by inhibiting TGFβ receptor signaling pathway. Our Stemolecule™ purmorphamine promotes differentiation of human and murine mesenchymal progenitor cells into osteoblasts by activating hedgehog signaling pathway. Our Stemgent™ mouse laminin provides more reproducible, defined conditions, making it a better cell attachment matrix for maintaining the undifferentiated state.