Profile: Spectrum Labs Inc. offers solutions for purification and bioprocessing. We offer hollow fiber modules, process systems, molecular/por UF membranes, molecular/por stirred cells, lab microfiltration systems, lab macrofiltration systems, HF cell culturing systems, HF filter accessories, cell processing systems, clear bath, transfertubes, medidroppers, micro tissue grinder, and dessicant plates. We also offer fraction collector & accessories, UV detector & accessories, chart recorder & replacement parts, solvent recycler and peristaltic pumps & accessories.

Spectrum Laboratories Cell Culture Division formerly Cellco Inc. manufactures hollow fiber bioreator systems designed to culture hybridoma, lymphocytes, endothelial cells and other cell types. We provide method for the serum-free production of packaged and infectious viral vectors in hollow fiber bioreator cartridge. The invention further concerns transducing target cells with the viral vectors. The invention is particularly suitable for producing transduced target cells free of adherent serum proteins. We have improved methods for producing high titers of recombinant viral vectors by culturing producer cells in a hollow fiber bioreactor. The titer of virus in the extra fiber space (EFS) of the hollow fiber bioreactor is sufficient to transduce target cells at a multiplicity of infection sufficient to render the transduced target cells useful for genetic therapy. In a preferred embodiment, target cells are transduced with the EFS medium from a hollow fiber bioreactor in which a producer cell line, which releases packaged retroviral vectors into the EFS, has been cultured.