Profile: ProFACT Proteomics, Inc. is an early-stage corporation. We apply SeraFILE™, a proprietary functional proteomics technology, to accelerate development of therapeutics and diagnostics, principally for cancer. We are highly experienced in developing & commercializing surface chemistries for biomolecule separations and sample preparation. We have developed surface library-SeraFILE™ for the subfraction of proteomes into sub-proteomes with reduced complexity and functional characteristics suitable for interrogation. The SeraFILE™ deliverable is functional proteomic data, alone or adjunctive to conventional proteomic data. It has immediate value in the discovery, early validation and assay development of biomarkers. Furthermore, as significant conformational events accompany the binding of drugs, the need to generate molecular profiles that characterize the function of one or more gene products working co-operatively is a paramount consideration in drug development. ProCipitate™ is a unique protein extraction reagent based upon patented elastomeric polyelectrolytes. The polymer chains of ProCipitate™ are initially extended in a high energy state due to an overall net negative charge. When introduced to protein solutions, the charges are neutralized and the polymer chains collapse to a more favorable energy state; DNA & RNA remain unreacted. ProCipitate™ is non-hazardous and can replace phenol/chloroform with the additional benefits of solid-phase suspensions. It is routinely used for plasmids, cosmids, BACs, and genomic DNA, as well as RNA. ProCipitate™ can also be used to remove proteinase K and other enzymes. ProCipitate™ provides DNA suitable for automated sequencing, Southern blotting, and restriction digestion.