Profile: PeptaNova GmbH is a distributor of biologically active peptides, enzyme - substrates, enzyme - inhibitors, and peptide anti-sera. We offer nine different adrenomedullin peptides or adrenomedullin peptide fragments including the proadrenomedullin n-terminal 20 peptide. Adrenomedullin (AM) is a potent vasoactive polypeptide composed of 52 amino acid residues, and may be seriously involved in the pathophysiology of chronic heart failure. Five adrenomedullin peptides were cloned and identified from pufferfish. Three of these are counterparts of the well known mammalian adrenomedullins. All offered adrenomedullin and proadrenomedullin peptides (PAMP) are totally synthetic peptides made by solid phase peptide synthesis, and are not manufactured by recombinant methods. Adrenomedullin with the human or the rat sequence, as well as the N-terminal adrenomedullin fragment AM (human, 1-25) is examined for biological activity by the pharmacological division.