Many different chemical moieties may be introduced into the cyclodextrin molecule by reaction with hydroxyl groups lining the upper and lower ridges of the toroid.For example methyl,hydroxy propyl,carboxymethyl and acetyl Since each cyclodextrin hydroxyl group differiIn its chemical reactivity the reaction produces an amorphous mixture of thousands of positional and optical isomers.The amorphous property contribute to the greatly enhanced solubility.The pharmaceutical usefulness of natural, crystalline cyclodextrins can be improved by chemical conversions into water-soluble, amorphous mixtures of their derivatives.