Profile: Galapagos NV is a drug discovery company. We have discovered new drug targets using human primary cells relevant for rheumatoid arthritis, osteoarthritis and osteoporosis. We apply these targets to find small molecules that change the activity of these proteins and thereby can influence the course of the disease. The molecules then form the basis for the development of medicines against these bone and joint diseases. This approach is expected to yield a breakthrough in treatment by stopping the disease rather than just treating the symptoms.