Profile: Clea Technologies B.V. specializes in the development of green and economically viable processes. We supply biocatalysts such as cross-linked enzyme aggregates of a broad selection of enzymes from various sources and other types of immobilized enzymes. Our selection of novel ionic liquids with good biodegradability and low ecotoxicity are used as solvents in chemical processes. Our stable n-oxy radical PIPO are used as a catalyst in alcohol oxidations. We perform screening studies on target compounds and optimize & scale-up reactions with guaranteed technology transfer. Our process R&D services help identify more alternatives for existing processes as well as innovative new processes. Our proprietary CLEA® technology is a very efficient and attractive method to immobilize enzymes. Since there is no added solid support, the final preparation is basically a pure protein with a very high concentration of enzyme per unit volume. Cross-linked enzyme aggregates are highly active and eminently reusable biocatalysts. This technology is straightforward and widely applicable to many different enzymes. This method can be carried out both with pure and crude enzyme preparations.