Cheminformatics, the combination of chemical synthesis, biological screening & data mining approaches used to guide drug discovery and development. Cheminformatic tools that allow for the rational selection of designed compounds with drug like properties from an almost infinite number of synthetic possibilities, building smarter focused libraries for virtual and high throughput screening & the exploitation of previously obtained discovery data to guide, lead optimization efforts that are all important. Chemoinformatics is the mixing of those information resources to transform data into information and information into knowledge for the intended purpose of making better decisions faster in the area of drug/lead identification & optimization. This area covers especially expert systems, algorithm development, information processing, storing chemical information, data mining, machine learning, structured data mining, databases, optimization problems, statistical analysis, chemometrics & data analysis.