Profile: Ascent Biosciences Corporation specializes in providing reagents and services for life science & drug discovery research. We specialize in tools for fluorescence analysis of cell and biochemical assays. We develop novel fluorescent sensors for use in biomedical research. These sensors find application in pharmaceutical drug discovery, genomics analysis, and life science research. Our Lewis acid reagent allows the measurement of kinase assays by fluorescence intensity (FI). When a fluorescent substrate becomes phosphorylated in the presence of a kinase and ATP, it can be detected by its binding to the Lewis acid component of the reagent, which enhances its fluorescence from 3 to 5 fold. This fluorescence enhancement accompanies very tight, practically covalent binding characteristic of phosphate ions in contact with a Lewis acid. As a result, kinase assays have very stable endpoints and good precision in FI mode. Phosphodiesterase substrates cAMP and cGMP can also bind upon hydrolysis by PDE, so that this reagent can be used to assay PDEs with fluorescent analogs of cAMP & cGMP. We offer a growing list of fluorescence reagents. FluoPass™ kit is especially designed for users of multimode plate readers who want to verify performance in FP and TRF modes. It can also be used for cuvette instruments and single mode readers. We have modern facilities for chemical synthesis and characterization. We provide services in custom synthesis and fluorescence labeling of peptides, proteins & bioactive molecules. We specialize in bioactive molecules and fluorophors. We can handle milligram to gram quantities and scale up. We also have a wide range of fluorescence labels from near UV to near IR.