The terms 'bioadhesive', 'biological adhesive', and 'surgical adhesive' are used interchangeably to refer to biocompatible compositions capable of effecting temporary or permanent attachment between the surfaces of two native tissues, or between a native tissue surface and a non-native tissue surface or a surface of a synthetic implant. In order to prepare the bioadhesive compositions, it is first necessary to provide collagen and a multifunctionally activated synthetic hydrophilic polymer.Collagen is the major protein component of bone, cartilage, skin, and connective tissue in animals.